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HPK1-IN-59

HPK1-IN-59 (compound 39) is an orally active HPK1 inhibitor with an IC50 of 0.70 nM. HPK1-IN-59 has favorable oral bioavailability in mice[1].

Product Specifications

UNSPSC

12352005

Target

MAP4K

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CC(C)(C1=CC(C2=CN(N=C2)CC(C)(O)C)=CC3=CN=C(N=C31)NC4=CC(C(C)(O5)C)=C(C=C4)C5=O)O

Molecular Formula

C28H31N5O4

Molecular Weight

501.58

References & Citations

[1]Wan B, et al. Structure-Guided Optimization of 2-Aminoquinazoline Hematopoietic Progenitor Kinase 1 Inhibitors for Improved Oral Bioavailability and Synergistic Antitumor Immunity. J Med Chem. 2025 May 22;68 (10) :10439-10460.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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