Orexin 2 Receptor Agonist 3
Orexin 2 Receptor Agonist 3 (Compound 57) is an orally active and brain-penetrant orexin receptor type-2 (OX2) agonist (EC50: 2.5 nM) . Orexin 2 Receptor Agonist 3 increases wakefulness in the orexin/ataxin-3 NT1 mouse model and healthy beagle dogs. Orexin 2 Receptor Agonist 3 can be used in the study of narcolepsy[1].
Product Specifications
UNSPSC
12352005
Target
Orexin Receptor (OX Receptor)
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
FC1=CC([C@H](C(NC2(C3)CC3(C)C2)=O)N(C4CC5(CC5)C4)C(CC6=C(C7=NN(C)N=N7)ON=C6)=O)=C(F)C=C1
Molecular Formula
C27H29F2N7O3
Molecular Weight
537.56
References & Citations
[1]Roecker AJ, et al. Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia. J Med Chem. 2016 Jan 28;59 (2) :504-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
OX2 Receptor
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