STING agonist-43
STING agonist-43 (Compound 67) is a selective STING agonist (EC50: 20.53 μM) . STING agonist-43 selectively amplifies cGAMP-dependent STING pathway activation by modulating STING oligomerization. B16.F10 has antitumor activity in a mouse melanoma model. STING agonist-43 can be used for the study of cancer immunity[1].
Product Specifications
CAS Number
[2882097-31-4]
UNSPSC
12352005
Target
STING
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1C2=C(N(C3=C(C(C)=C(C=C31)OC)C)CC(OCC)=O)C=CC(C)=C2
Molecular Formula
C21H23NO4
Molecular Weight
353.41
References & Citations
[1]Hou S, et al. Design, Synthesis, and Biological Evaluation of Selective STING Synergists That Enhance cGAMP-STING Pathway Activation without Inherent Agonist Activity. J Med Chem. 2025 May 8;68 (9) :9407-9430.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-172671/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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