Spore germination-IN-1

Spore germination-IN-1 (Compound 110) is an orally active spore germination inhibitor (IC50: 14 μM) . Spore germination-IN-1 specifically inhibits the enzymatic activities of mature SleC and CspB on spores (Kd: 12 and 8 μM) . Spore germination-IN-1 can be used in studies against C. difficile[1].

Product Specifications

UNSPSC

12352005

Target

Fungal

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Concentration

10mM

Purity

98.67

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC(F)(F)C1=CC=C(C=C1)OC2=CC(C3=NOC(C4=CC=C(CN)C=C4)=N3)=CC=N2.Cl

Molecular Formula

C21H16ClF3N4O2

Molecular Weight

448.83

References & Citations

[1]Yang J, et al. Targeting SleC and CspB in the Inhibition of Spore Germination in Clostridioides difficile. J Med Chem. 2025 May 8;68 (9) :9357-9370.