Trabectedin derivative 1 (TFA)
Trabectedin derivative 1 TFA is a selective DNA minor groove binder. Trabectedin derivative 1 TFA inhibits DNA transcription and repair to induce tumor cell apoptosis. Trabectedin derivative 1 TFA is promising for research of solid tumors such as soft tissue sarcoma and ovarian cancer[1].
Product Specifications
UNSPSC
12352211
Target
Apoptosis; DNA/RNA Synthesis
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Purity
99.32
Solubility
DMSO : ≥ 100 mg/mL
Smiles
N#C[C@@H]([C@]1([H])CC2=CC(C)=C3OC)N([C@](CO4)([H])C5=C(OCO6)C6=C7C)[C@@]([C@@](N1C)([H])C2=C3O)([H])[C@@](SC[C@](C8=CC(OC)=C9N)(NCCC8=C9)C4=O)([H])C5=C7OC(C)=O.O=C(O)C(F)(F)F
Molecular Formula
C42H44F3N5O11S
Molecular Weight
883.89
References & Citations
[1]Bin Zou, et al. Anti-alpp/alppl2 antibodies, antibody-drug conjugates, and uses thereof. WO2025048716A1. 2025-03-06.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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