TRF1-TIN2 PPI-IN-1
TRF1-TIN2 PPI-IN-1 (Compound 40) is a TRF1-TIN2 interaction inhibitor. TRF1-TIN2 PPI-IN-1 binds to the TRFH domain of TRF1 (KD = 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50 = 67 μM) . TRF1-TIN2 PPI-IN-1 disrupts the interaction between TRF1 and TIN2 by occupying the hotspot region of the TRF1-TIN2 binding interface. TRF1-TIN2 PPI-IN-1 can expel TRF 1 from the shelterin complex and can be used to study shelterin-related cancers[1].
Product Specifications
UNSPSC
12352005
Target
Telomerase
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Concentration
10mM
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OS(C1=CC=C(OCC2=CC(OC)=CC(OC)=C2)C3=C1C=CC=C3)(=O)=O
Molecular Formula
C19H18O6S
Molecular Weight
374.41
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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