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36R-D481

36R-D481 is a competitive and orthosteric antagonist of IL-36R, effectively inhibiting IL-36 signaling. 36R-D481 can inhibit IL-36α and IL-36γ but not IL-36β induced IL-8 release[1].

Product Specifications

UNSPSC

12352005

Target

Interleukin Related

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=NNC2=C1CN(C3=C(C#N)C=NC4=C3C=C(C(O)=O)S4)CC2)N[C@H](C5=CC(Br)=CC=C5)CC(NCCOCCN6CCOCC6)=O

Molecular Formula

C33H35BrN8O6S

Molecular Weight

751.65

References & Citations

[1]Velcicky J, et, al. Discovery of selective low molecular weight interleukin-36 receptor antagonists by encoded library technologies. Nat Commun. 2025 Feb 15;16 (1) :1669.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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