36R-D481
36R-D481 is a competitive and orthosteric antagonist of IL-36R, effectively inhibiting IL-36 signaling. 36R-D481 can inhibit IL-36α and IL-36γ but not IL-36β induced IL-8 release[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=NNC2=C1CN(C3=C(C#N)C=NC4=C3C=C(C(O)=O)S4)CC2)N[C@H](C5=CC(Br)=CC=C5)CC(NCCOCCN6CCOCC6)=O
Molecular Formula
C33H35BrN8O6S
Molecular Weight
751.65
References & Citations
[1]Velcicky J, et, al. Discovery of selective low molecular weight interleukin-36 receptor antagonists by encoded library technologies. Nat Commun. 2025 Feb 15;16 (1) :1669.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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