(S, R, S) -AHPC-Me-amide-C-O-C5-Br
(S, R, S) -AHPC-Me-amide-C-O-C5-Br incorporates an VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S, R, S) -AHPC-Me-amide-C-O-C5-Br can be used to design PROTACs, such as ERD-308.
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
BrCCCCCOCC(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)=O
Molecular Formula
C30H43BrN4O5S
Molecular Weight
651.66
References & Citations
[1]Hu J, et al. Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER) . J Med Chem. 2019 Feb 14;62 (3) :1420-1442.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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