VH 101-amide-piperidine-Pip-alkyne
VH 101-amide-piperidine-Pip-alkyne is an E3 Ligase Ligand-Linker Conjugates that can be used to synthesize PROTAC degrader. The linker part of VH 101-amide-piperidine-Pip-alkyne is tert-Butyl 4-ethynyl-[1,4'-bipiperidine]-1'-carboxylate (HY-W442074), and the VHL-type E3 ubiquitinase ligand is VH 101, acid (HY-47070) [1].
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
C#CC1CCN(C2CCN(C(C[C@H](NC([C@H]3N(C([C@@H](NC(C4(CC4)F)=O)C(C)(C)C)=O)C[C@H](O)C3)=O)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)CC2)CC1
Molecular Formula
C40H53FN6O5S
Molecular Weight
748.95
References & Citations
[1]Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem. 2019 Jan 24;62 (2) :941-964.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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