AR antagonist 14
AR antagonist 14 is is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC) . AR antagonist 14 can be combined with VH 101-amide-piperidine-Pip-alkyne (HY-172625) to synthesize PROTAC degraders (ARD-69 (HY-114402) ) [1].
Product Specifications
CAS Number
[2757424-54-5]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
ClC1=CC(O[C@H]2C(C)(C)[C@H](NC(C3=CC=C(I)C=C3)=O)C2(C)C)=CC=C1C#N
Molecular Formula
C22H22ClIN2O2
Molecular Weight
508.78
References & Citations
[1]Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem. 2019 Jan 24;62 (2) :941-964.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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