EGFR-IN-159

EGFR-IN-159 (compound 12), a dihydropyrimidine, is a potent EGFR inhibitor with an IC50 value of 29.00 nM. EGFR-IN-159 exhibits dose-dependent inhibition against EGFR and HER2. EGFR-IN-159 shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 has no BBB permeation. EGFR-IN-159 shows appreciable anti-cancer activity[1].

Product Specifications

CAS Number

[2055746-08-0]

UNSPSC

12352005

Target

EGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

OC1=C(OCC)C=C(C2C(C(NC3=C(OC)C=CC=C3)=O)=C(C)NC(N2)=O)C=C1

Molecular Formula

C21H23N3O5

Molecular Weight

397.42

References & Citations

[1]Ruby Mariam Raju, et al. Computational and experimental approach to develop novel Biginelli dihydropyrimidines as EGFR inhibitors against breast cancer. Journal of Molecular Structure, 2025, 1328: 141226.