LIB3S0280

LIB3S0280 is a potent TBK1 inhibitor with an IC50 value of 493.9 nM. LIB3S0280 exhibits better anticancer effects in pancreatic cancer cell lines with high TBK1 expression. LIB3S0280 inhibits TBK1 downstream signaling pathways, including PI3K/AKT and NF-κB. LIB3S0280 induces G2/M arrest, apoptosis and cellular senescence. LIB3S0280 can be used for pancreatic ductal adenocarcinoma (PDAC) research[1].

Product Specifications

UNSPSC

12352005

Target

Akt; Apoptosis; Caspase; CDK; IKK; NF-κB; PARP; PI3K

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; NF-κB; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease; Inflammation/Immunology; Metabolic Disease

Purity

99.89

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=C(OC)C=C(CCNC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Cl)C=C1

Molecular Formula

C22H25ClN4O5

Molecular Weight

460.91

References & Citations

[1]Wan-Hsi Shih, et al. Discovery of novel TANK-Binding Kinase 1 (TBK1) inhibitor against pancreatic ductal adenocarcinoma. Int J Biol Macromol. 2024 Dec;283 (Pt 1) :137296.