BS-153
BS-153 is a novel synthetic oxazolidinone agent with anti-inflammatory activities by blocking the activation of the NF-κB/PKCθ pathway. BS-153 inhibits the expression levels of iNOS and COX-2 and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) on LPS-stimulated RAW264.7 cells[1].
Product Specifications
CAS Number
[1935692-54-8]
UNSPSC
12352005
Target
NF-κB
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
FC(F)(F)C1=C(NC(C2=CC=C(N3CCC(N4CCOCC4)CC3)C(C#N)=C2)=O)C=NN1C5=CC=C(Cl)C=C5
Molecular Formula
C27H26ClF3N6O2
Molecular Weight
558.98
References & Citations
[1]Liyan Xu, et al. A novel synthetic oxazolidinone derivative BS-153 attenuated LPS-induced inflammation via inhibiting NF-κB/pkcθ signaling pathway. Fish Shellfish Immunol. 2025 Jun:161:110292.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-172619/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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