BS-153

BS-153 is a novel synthetic oxazolidinone agent with anti-inflammatory activities by blocking the activation of the NF-κB/PKCθ pathway. BS-153 inhibits the expression levels of iNOS and COX-2 and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) on LPS-stimulated RAW264.7 cells[1].

Product Specifications

CAS Number

[1935692-54-8]

UNSPSC

12352005

Target

NF-κB

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

FC(F)(F)C1=C(NC(C2=CC=C(N3CCC(N4CCOCC4)CC3)C(C#N)=C2)=O)C=NN1C5=CC=C(Cl)C=C5

Molecular Formula

C27H26ClF3N6O2

Molecular Weight

558.98

References & Citations

[1]Liyan Xu, et al. A novel synthetic oxazolidinone derivative BS-153 attenuated LPS-induced inflammation via inhibiting NF-κB/pkcθ signaling pathway. Fish Shellfish Immunol. 2025 Jun:161:110292.