APD-94
APD-94 is a dual inhibitor targeting tubulin and Bmi-1. APD-94 interfers tubulin normal polymerization. APD-94 suppresses the expression of Bmi-1. APD-94 causes cell cycle arrest at the G2/M phase in cancer cells and induces apoptosis, thus inhibiting cancer cell proliferation. APD-94 represses the growth of HT29 cell xenografts in NOD/SCID mice. APD-94 can be used for colorectal cancer study[1].
Product Specifications
CAS Number
[877810-03-2]
UNSPSC
12352005
Target
Apoptosis; BMI1; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt
Field of Research
Cancer
Smiles
COC1=CC(O)=C(C2=NC(N)=NC=C2OC3=CC(OC)=CC=C3)C=C1
Molecular Formula
C18H17N3O4
Molecular Weight
339.35
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-172617/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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