AMPTX-1
AMPTX-1, a molecular glue, a potent and selective, reversibly covalent BRD9 degrader via recruitment of BRD9 to the E3 ligase DCAF16[1].
Product Specifications
CAS Number
3033019-04-1
UNSPSC
12352005
Target
Epigenetic Reader Domain; Molecular Glues
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.00
Solubility
DMSO : ≥ 100 mg/mL
Smiles
N#C/C(C(N1CCC2=C(C1C)C=CC=C2CN3CCN(CC34CC4)CC5=C(OC)C=C(C6=CN(C)C(C(C)=C6C)=O)C=C5OC)=O)=C\C(C)(C)C
Molecular Formula
C42H53N5O4
Molecular Weight
691.90
References & Citations
[1]Scott J. Hughes, et al. Selective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of concept. bioRxiv. January 02, 2025.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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