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RK-0080552

RK-0080552 (RK-552) is a NSD2 histone methyltransferase inhibitor. RK-0080552 demonstrates significant cytotoxicity against multiple myeloma (MM) cells carrying t (4;14) . RK-0080552 suppresses the IRF4 gene, reducing the level of histone H3 lysine 36 dimethylation. RK-0080552 is promising for research of hematological malignancies[1].

Product Specifications

CAS Number

313527-11-6

Product Name Alternative

RK-552

UNSPSC

12352005

Target

Histone Methyltransferase

Related Pathways

Epigenetics

Field of Research

Cancer

Smiles

NC1=NON=C1C(N=N2)=NC3=C2C(C4=C3C=CC=C4)=O

Molecular Formula

C12H6N6O2

Molecular Weight

266.22

References & Citations

[1]Matsuoka S, et al. Discovery of a novel class NSD2 inhibitor for t (4; 14) -positive multiple myeloma[J]. Blood Neoplasia, 2025: 100091.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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