HDAC3-IN-7

HDAC3-IN-7 (Compound 8ae) is a selective HDAC3 inhibitor with an IC50 value of 311 nM. HDAC3-IN-7 degrades PD-L1 through the lysosome pathway mediated by Cathepsin B, exerting activities such as inhibiting tumor cell proliferation, migration, and invasion. HDAC3-IN-7 is promising for research of cancers[1].

Product Specifications

UNSPSC

12352211

Target

HDAC; PD-1/PD-L1

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(NNCCC)CCCCCCNC(C1=CN=C(C2=CC=C(NC(OC(C)(C)C)=O)C=C2)S1)=O

Molecular Formula

C25H37N5O4S

Molecular Weight

503.66

References & Citations

[1]Hu Z, et al. Design, synthesis and bioevaluation of novel hydrazide derivatives as enhancers of immunotherapy and DNA-damage response in antitumor therapy. Eur J Med Chem. 2025 Apr 7;291:117601.