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Keap1-Nrf2-IN-28

Keap1-Nrf2-IN-28 (SG16) is an orally active Keap1-Nrf2 inhibitor. Keap1-Nrf2-IN-28 shows antioxidant capability and induces the upregulation of Nrf2, HO-1, GCLM, and Akr1c1. Keap1-Nrf2-IN-28 attenuates APAP -induced acute liver injury[1].

Product Specifications

CAS Number

3075750-60-3

UNSPSC

12352005

Target

Keap1-Nrf2

Related Pathways

NF-κB

Field of Research

Inflammation/Immunology

Smiles

O=S(C1=CC=C(F)C=C1)(NC2=CC3=C(C=C2)C(C=C(C4=CC=C(OC)C=C4)O3)=O)=O

Molecular Formula

C22H16FNO5S

Molecular Weight

425.43

References & Citations

[1]Sang Y, et al. Fluorinated sulfonamide-flavonoid derivatives as novel Keap1-Nrf2 inhibitors: Potent induction of cytoprotective gene HO-1 in vivo. Eur J Med Chem. 2025 Jul 5;291:117650.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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