YL-1-9
YL-1-9 is an inhibitor of the degradation of p53 by MDM2 through strong binding to the key hydrophobic pockets of MDM2. YL-1-9 induces cell cycle arrest and apoptosis in breast cancer cells[1].
Product Specifications
CAS Number
[3064304-12-4]
UNSPSC
12352005
Target
Apoptosis; CDK; MDM-2/p53
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(NC1=CC(C(F)(F)F)=C(CN2CCC(C)CC2)C=C1)C3=CC(OCO4)=C4C=C3
Molecular Formula
C22H23F3N2O3
Molecular Weight
420.42
References & Citations
[1]Chongyun Zhou, et al. The novel Piperine derivative YL-1-9 exhibits anti-breast Cancer effects by inducing apoptosis via the p53/p21 pathway. Bioorg Med Chem Lett. 2025 Aug 1:123:130231.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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