TYK2 activator-1
TYK2 activator-1 (16b) is a TYK2 activator with anEC50 of 1.78 μM. TYK2 activator-1 inhibits JAK2 and JAK3 with the IC50 values of 6.8 and 6.3 μM, respectively[1].
Product Specifications
CAS Number
3087219-47-1
UNSPSC
12352005
Target
JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
COC1=C(C#C)C=CC=C1NC2=CC(NC3=CC(C)=C(F)C=N3)=NC=C2C(NC)=O
Molecular Formula
C22H20FN5O2
Molecular Weight
405.42
References & Citations
[1]Matsumoto H, et al. Identification of small molecule activators targeting TYK2 pseudokinase domain. Bioorg Med Chem Lett. 2025 Aug 1;123:130233.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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