CB1R Allosteric modulator 5
CB1R Allosteric modulator 5 (compound 3) is a selective, and blood-brain barrier (BBB) permeable Cannabinoid receptor type 1 allosteric modulator with a pIC50 of 6.89. CB1R Allosteric modulator 5 attenuates both cocaine-seeking behavior specific to cue-induced reinstatement and cocaine-induced behavioral sensitization without altering locomotor activity[1].
Product Specifications
CAS Number
3019958-44-9
UNSPSC
12352005
Target
Cannabinoid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Purity
98.35
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(NC2=CC=C(Cl)C=C2)=C(NCCC3=CC(Cl)=CC=C3)C1=O
Molecular Formula
C18H14Cl2N2O2
Molecular Weight
361.22
References & Citations
[1]Nguyen T, et al. Development of Squaramides as Allosteric Modulators of the CB1 Receptor: Synthesis, Computational Studies, Biological Characterization, and Effects against Cocaine-Induced Behavioral Sensitization and Reinstatement in Rats. J Med Chem. 2025 Apr 24;68 (8) :8694-8712.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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