GSK-3α/β-IN-1
GSK-3α/β-IN-1 is GSK-3α/β inhibitor with IC50 s of 0.265 μM and 0.255 μM for GSK-3α and GSK-3β, respectively. GSK-3α/β-IN-1 also inhibits PKA with an IC50 of 0.188 μM. GSK-3α/β-IN-1 potently inhibits cell viability of three Glioblastoma (GBM) cell lines (IC50 : 3-6 μM, 72 h) with no toxicity to human astrocytes and good metabolic stability. GSK-3α/β-IN-1 has potential CNS activity in all-human blood-brain barrier (BBB) model of GBM[1].
Product Specifications
CAS Number
1574354-24-7
UNSPSC
12352005
Target
GSK-3; PKA
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Smiles
OC1=CC=C(C2=NC(NN=C3)=C3C(C4=CC=C(C(C)C)C=C4)=C2O5)C5=C1
Molecular Formula
C21H17N3O2
Molecular Weight
343.38
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3α; GSK-3β; PKA
Frequently Asked Questions
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