Kv7.2/Kv7.3 modulator-1

Kv7.2/Kv7.3 modulator-1 (compound 6a) is a Kv7.2/Kv7.3 modulator with the pEC50 of 7.96 (KV7.2/3 channel opening activity) . Kv7.2/Kv7.3 modulator-1 can be used for study of epilepsy, depression, brain injury and pain[1].

Product Specifications

CAS Number

[2981435-42-9]

UNSPSC

12352005

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

CC1=C(C(NCC2=CC=C(F)C=C2)=O)C(OCC(F)(F)F)=NC(N3CCOCC3)=C1

Molecular Formula

C20H21F4N3O3

Molecular Weight

427.39

References & Citations

[1]Lemke J, et al. Lead Optimization of Positive Allosteric KV7.2/3 Channel Modulators toward Improved Balance of Lipophilicity and Aqueous Solubility. J Med Chem. 2025 Apr 24;68 (8) :8377-8399.