Anti-TNBC agent-9
Anti-TNBC agent-9 (Compound 3as) is an anti-cancer agent for triple-negative breast cancer (TNBC) . anti-TNBC agent-9 exhibits significant inhibitory activity against MDA-MB-453 cells with an IC50 value of 8.5 μM. anti-TNBC agent-9 inhibits tumor cell migration by upregulating E-cadherin and downregulating N-cadherin, matrix metalloproteinase 2 (MMP2), and MMP9. anti-TNBC agent-9 induces apoptosis by increasing the expression of the pro-apoptotic protein BAX and decreasing the expression of the anti-apoptotic protein BCL-2, thereby inhibiting tumor cell proliferation[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Cadherin; MMP
Related Pathways
Apoptosis; Cytoskeleton; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C([C@@]12CC(NC(C(F)(F)F)=O)=C[C@@H](C3=CC=CS3)[C@]14C(N(C5=CC=CC=C5)N=C4C)=O)N(CC6=CC=CC=C6)C7=C2C=CC=C7
Molecular Formula
C35H27F3N4O3S
Molecular Weight
640.67
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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