Anti-TNBC agent-9

Anti-TNBC agent-9 (Compound 3as) is an anti-cancer agent for triple-negative breast cancer (TNBC) . anti-TNBC agent-9 exhibits significant inhibitory activity against MDA-MB-453 cells with an IC50 value of 8.5 μM. anti-TNBC agent-9 inhibits tumor cell migration by upregulating E-cadherin and downregulating N-cadherin, matrix metalloproteinase 2 (MMP2), and MMP9. anti-TNBC agent-9 induces apoptosis by increasing the expression of the pro-apoptotic protein BAX and decreasing the expression of the anti-apoptotic protein BCL-2, thereby inhibiting tumor cell proliferation[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Cadherin; MMP

Related Pathways

Apoptosis; Cytoskeleton; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C([C@@]12CC(NC(C(F)(F)F)=O)=C[C@@H](C3=CC=CS3)[C@]14C(N(C5=CC=CC=C5)N=C4C)=O)N(CC6=CC=CC=C6)C7=C2C=CC=C7

Molecular Formula

C35H27F3N4O3S

Molecular Weight

640.67

References & Citations

[1]Hou Q, et al. Catalyst-controlled regiodivergence and stereodivergence in formal cross-[4+2] cycloadditions: The unique effect of bismuth (III) . Sci Adv. 2025 Mar 28;11 (13) :eadt5997.