MS7710
MS7710 is a brain-penetrant inhibitor targeting the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. MS7710 reduces the Ih current and decreases the activity of ventral tegmental area (VTA) dopamine neurons by inhibiting HCN channels. MS7710 can effectively improve social interaction deficits and reward-related cognitive flexibility in the chronic social defeat stress (CSDS) mouse model. MS7710 is promising for research of depression[1].
Product Specifications
UNSPSC
12352005
Target
HCN Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Purity
98.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=CC(OCCN2CCC[C@H](CN3C(CC(C=C(OC)C(OC)=C4)=C4CC3)=O)C2)=C1
Molecular Formula
C27H36N2O5
Molecular Weight
468.59
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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