MS7710

MS7710 is a brain-penetrant inhibitor targeting the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. MS7710 reduces the Ih current and decreases the activity of ventral tegmental area (VTA) dopamine neurons by inhibiting HCN channels. MS7710 can effectively improve social interaction deficits and reward-related cognitive flexibility in the chronic social defeat stress (CSDS) mouse model. MS7710 is promising for research of depression[1].

Product Specifications

UNSPSC

12352005

Target

HCN Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Purity

98.86

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=CC(OCCN2CCC[C@H](CN3C(CC(C=C(OC)C(OC)=C4)=C4CC3)=O)C2)=C1

Molecular Formula

C27H36N2O5

Molecular Weight

468.59

References & Citations

[1]Teichman EM, et al. Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype. Mol Psychiatry. 2025 Apr 8.