Lyso-monosialoganglioside GM2 (ammonium)

Lyso-monosialoganglioside GM2 (LysoGM2) ammonium is a lysosphingolipid and protein kinase C inhibitor (IC50: 50 μM) . Lyso-monosialoganglioside GM2 ammonium can inhibit the binding of protein kinase C to Phorbol 12,13-dibutyrate (HY-18985) . Lyso-monosialoganglioside GM2 ammonium is a specific biomarker for GM2 gangliosidosis. Lyso-monosialoganglioside GM2 ammonium can be used in the research of sphingolipidoses[1][2].

Product Specifications

Product Name Alternative

LysoGM2 (ammonium)

UNSPSC

12352211

Target

PKC

Related Pathways

Epigenetics; TGF-beta/Smad

Field of Research

Metabolic Disease

Smiles

N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2[C@H](O)[C@@H](O[C@@]3(C[C@@H]([C@H]([C@@]([H])(O3)[C@H](O)[C@@H](CO)O)NC(C)=O)O)C([O-])=O)[C@@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4NC(C)=O)[C@@H](CO)O2)[C@H](O)[C@H]1O)[C@@H](/C=C/CCCCCCCCCCCCC)O.[NH4+]

Molecular Formula

C49H90N4O25

Molecular Weight

1135.25

References & Citations

[1]Ducatez F, et al. Lysosphingolipid Quantitation in Plasma and Dried-Blood Spots Using Targeted High-Resolution Mass Spectrometry. J Clin Lab Anal. 2025 Jan;39 (1) :e25131.|[2]Hannun YA, et al. Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science. 1987 Feb 6;235 (4789) :670-4.