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TTBK1/2-IN-2

TTBK1/2-IN-2 (compound 9) is a potent Tau tubulin kinase 1 (TTBK1) and TTBK2 inhibitor with IC50s of 384 nM and 175 nM, respectively. TTBK1/2-IN-2 shows a significant ciliogenesis phenotype in human induced pluripotent stem cells (iPSCs) [1].

Product Specifications

CAS Number

2857982-35-3

UNSPSC

12352005

Target

Tau Protein

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

OC(CC)(CC)C#CC1=CC2=C(NC3=C2C4=C(C=NC(N)=N4)CCC3)C=C1

Molecular Formula

C22H24N4O

Molecular Weight

360.45

References & Citations

[1]Bashore FM, et al. Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis. Sci Rep. 2023 Apr 14;13 (1) :6118.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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