BPN-01
BPN-01 is a fluorescent probe targeting translocator protein (TSPO) and human epidermal growth factor receptor 2 (HER2) with binding affinities of -10.7 kcal/mol for TSPO and -11.3 kcal/mol for HER2. BPN-01 is promising for research of solid tumor imaging during fluorescence image-guided surgery (FIGS) (Ex/Em = 475/510 nm) [1].
Product Specifications
UNSPSC
12352005
Target
EGFR; Fluorescent Dye; TSPO
Related Pathways
JAK/STAT Signaling; Neuronal Signaling; Others; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=CC=C2C(SC(C(NC3=CC=C(C=C3)CNC4=CC=C(C5=NON=C45)[N+]([O-])=O)=O)=N2)=C1
Molecular Formula
C22H16N6O5S
Molecular Weight
476.46
References & Citations
[1]Wongso H, et al. Synthesis and Biological Evaluation of New Fluorescent Probe BPN-01: A Model Molecule for Fluorescence Image-guided Surgery. J Fluoresc. 2023 Sep;33 (5) :1827-1839.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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