BPN-01

BPN-01 is a fluorescent probe targeting translocator protein (TSPO) and human epidermal growth factor receptor 2 (HER2) with binding affinities of -10.7 kcal/mol for TSPO and -11.3 kcal/mol for HER2. BPN-01 is promising for research of solid tumor imaging during fluorescence image-guided surgery (FIGS) (Ex/Em = 475/510 nm) [1].

Product Specifications

UNSPSC

12352005

Target

EGFR; Fluorescent Dye; TSPO

Related Pathways

JAK/STAT Signaling; Neuronal Signaling; Others; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

COC1=CC=C2C(SC(C(NC3=CC=C(C=C3)CNC4=CC=C(C5=NON=C45)[N+]([O-])=O)=O)=N2)=C1

Molecular Formula

C22H16N6O5S

Molecular Weight

476.46

References & Citations

[1]Wongso H, et al. Synthesis and Biological Evaluation of New Fluorescent Probe BPN-01: A Model Molecule for Fluorescence Image-guided Surgery. J Fluoresc. 2023 Sep;33 (5) :1827-1839.