Sulfonadyn-47
Sulfonadyn-47 is a GTP-competitive dynamin I (dynI) inhibitor that targets the active site in the GTPase domain of dynamin I, with IC50 values of 3.5 μM against dynI, 27.3 μM in clathrin-mediated endocytosis (CME) assays, and 12.3 μM in synaptic vesicle endocytosis (SVE) assays. Sulfonadyn-47 increases seizure threshold. Sulfonadyn-47 can be used the study for the seizure[1].
Product Specifications
CAS Number
[3064686-59-2]
UNSPSC
12352005
Target
Dynamin; Ras
Related Pathways
Cytoskeleton; GPCR/G Protein; MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
BrC1=CC=C(C=C1)/C=C/CNCCCNS(=O)(C2=C3C=CC=CC3=CC=C2)=O
Molecular Formula
C22H23BrN2O2S
Molecular Weight
459.40
References & Citations
[1]Odell LR, et al. The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models. RSC Med Chem. 2023 Apr 26;14 (8) :1492-1511.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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