Sulfonadyn-47

Sulfonadyn-47 is a GTP-competitive dynamin I (dynI) inhibitor that targets the active site in the GTPase domain of dynamin I, with IC50 values of 3.5 μM against dynI, 27.3 μM in clathrin-mediated endocytosis (CME) assays, and 12.3 μM in synaptic vesicle endocytosis (SVE) assays. Sulfonadyn-47 increases seizure threshold. Sulfonadyn-47 can be used the study for the seizure[1].

Product Specifications

CAS Number

[3064686-59-2]

UNSPSC

12352005

Target

Dynamin; Ras

Related Pathways

Cytoskeleton; GPCR/G Protein; MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

BrC1=CC=C(C=C1)/C=C/CNCCCNS(=O)(C2=C3C=CC=CC3=CC=C2)=O

Molecular Formula

C22H23BrN2O2S

Molecular Weight

459.40

References & Citations

[1]Odell LR, et al. The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models. RSC Med Chem. 2023 Apr 26;14 (8) :1492-1511.