Enpp-1/3-IN-1
Enpp-1/3-IN-1 (Compound 5j) is an ENPP1/ENPP3 inhibitor, with IC50s of 0.59 μM (h-ENPP1) and 0.62 μM (h-ENPP3) respectively. Enpp-1/3-IN-1 also inhibits e5′NT (CD73) and TNAP with IC50s of 0.89 μM (h-e5′NT), 5.12 μM (r-e5′NT) and 1.68 μM (h-TNAP), respectively. Enpp-1/3-IN-1 can be used for cancer research[1].
Product Specifications
UNSPSC
12352005
Target
CD73; Phosphatase; Phosphodiesterase (PDE)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(CC1=CNC2=CC=CC=C21)NC3=CC=CC=C3OS(C(F)(F)F)(=O)=O
Molecular Formula
C17H13F3N2O4S
Molecular Weight
398.36
References & Citations
[1]Khan Jadoon MS, et al. Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors. RSC Adv. 2023 Oct 10;13 (42) :29496-29511.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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