CD73-IN-20
CD73-IN-20 (Compound 5c) is an e5′NT (CD73) inhibitor (IC50: 0.37 μM) . CD73-IN-20 also inhibits other ectonucleotidases, with IC50s of 1.12 μM (h-ENPP1), 1.37 μM (h-ENPP3), 1.66 μM (r-e5′NT), 1.48 μM (h-TNAP), respectively. CD73-IN-20 can be used for cancer research[1].
Product Specifications
UNSPSC
12352005
Target
CD73; Phosphatase; Phosphodiesterase (PDE)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(CC1=CNC2=CC=CC=C21)NC3=CC=CC=C3OS(C4=CC=C(C=C4)F)(=O)=O
Molecular Formula
C22H17FN2O4S
Molecular Weight
424.44
References & Citations
[1]Khan Jadoon MS, et al. Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors. RSC Adv. 2023 Oct 10;13 (42) :29496-29511.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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