(1R,2S,3R) -Aprepitant

(1R,2S,3R) -Aprepitant (Compound ent-4) is a competitive human neurokinin-1 (NK-1) receptor antagonist. (1R,2S,3R) -Aprepitant is promising for research of cancers and postoperative nausea and vomiting[1].

Product Specifications

CAS Number

[1185502-97-9]

UNSPSC

12352005

Target

Neurokinin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cancer

Smiles

C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)O[C@H](OCC2)[C@@H](C3=CC=C(C=C3)F)N2CC4=NNC(N4)=O

Molecular Formula

C23H21F7N4O3

Molecular Weight

534.43

References & Citations

[1]Kulangiappar K, et al. Synthetic communications: an international journal for rapid communication of synthetic organic chemistry[J]. Synthetic Communications, 2014, 1 (44) : 2494-2502.