AChE/BChE/MAO-B-IN-5
AChE/BChE/MAO-B-IN-5 is a multitarget inhibitor of cholinesterases (AChE and BChE) and monoamine oxidase MAO-B with blood–brain barrier permeability. It exhibits IC50 values of 0.24 µM, 6.29 µM, and 0.11 µM against AChE, BChE, and MAO-B, respectively. AChE/BChE/MAO-B-IN-5 shows promise for research in the field of neurodegenerative diseases such as Alzheimer's disease[1].
Product Specifications
CAS Number
1432738-00-5
UNSPSC
12352101
Target
Cholinesterase (ChE) ; Monoamine Oxidase
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C1N(CC2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C=C2)C(C4=C1C=CC=C4)=O
Molecular Formula
C22H14F3NO2
Molecular Weight
381.35
References & Citations
[1]Abdullah N, et al. Synthesis, Pharmacological Evaluation, and Molecular Modeling of Phthalimide Derivatives as Monoamine Oxidase and Cholinesterase Dual Inhibitors. ACS Omega. 2025 Mar 4;10 (10) :10385-10400.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; MAO-B
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