AChE/BChE/MAO-B-IN-5

AChE/BChE/MAO-B-IN-5 is a multitarget inhibitor of cholinesterases (AChE and BChE) and monoamine oxidase MAO-B with blood–brain barrier permeability. It exhibits IC50 values of 0.24 µM, 6.29 µM, and 0.11 µM against AChE, BChE, and MAO-B, respectively. AChE/BChE/MAO-B-IN-5 shows promise for research in the field of neurodegenerative diseases such as Alzheimer's disease[1].

Product Specifications

CAS Number

[1432738-00-5]

UNSPSC

12352101

Target

Cholinesterase (ChE) ; Monoamine Oxidase

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C1N(CC2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C=C2)C(C4=C1C=CC=C4)=O

Molecular Formula

C22H14F3NO2

Molecular Weight

381.35

References & Citations

[1]Abdullah N, et al. Synthesis, Pharmacological Evaluation, and Molecular Modeling of Phthalimide Derivatives as Monoamine Oxidase and Cholinesterase Dual Inhibitors. ACS Omega. 2025 Mar 4;10 (10) :10385-10400.