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NUCC-0200808

NUCC-0200808 (Compound 12g) is an inhibitor of MNK1 with an IC50 of 42 nM. NUCC-0200808 reduces eIF4E phosphorylation and cell viability in AML cells, and induces apoptosis. NUCC-0200808 holds promise for research in the field of leukemia[1].

Product Specifications

UNSPSC

12352005

Target

MNK

Related Pathways

MAPK/ERK Pathway

Field of Research

Cancer

Smiles

ClC1=CN=C(N2C=NC3=C2C=CC=C3)N=C1OC4CCNC4

Molecular Formula

C15H14ClN5O

Molecular Weight

315.76

References & Citations

[1]Vagadia PP, et al. Discovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia. J Med Chem. 2025 Mar 13;68 (5) :5824-5844.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MNK1; MNK2

Frequently Asked Questions

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