NUCC-0200808
NUCC-0200808 (Compound 12g) is an inhibitor of MNK1 with an IC50 of 42 nM. NUCC-0200808 reduces eIF4E phosphorylation and cell viability in AML cells, and induces apoptosis. NUCC-0200808 holds promise for research in the field of leukemia[1].
Product Specifications
UNSPSC
12352005
Target
MNK
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Smiles
ClC1=CN=C(N2C=NC3=C2C=CC=C3)N=C1OC4CCNC4
Molecular Formula
C15H14ClN5O
Molecular Weight
315.76
References & Citations
[1]Vagadia PP, et al. Discovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia. J Med Chem. 2025 Mar 13;68 (5) :5824-5844.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MNK1; MNK2
Curated Selection
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