JSF-4898
JSF-4898 is an orally active inhibitor of the MenG enzyme in Mycobacterium tuberculosis. JSF-4898 has MIC of 0.78 μM against Mycobacterium tuberculosis H37Rv. JSF-4898 can enhance the efficacy of Rifampicin (HY-B0272) in a subacute model of Mycobacterium tuberculosis infection in mice[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(NC1=CC(C2=CCC(C(NC)=O)CC2)=C(OC)N=C1)C3=CC=C(F)C=C3Cl
Molecular Formula
C21H21ClFN3O3
Molecular Weight
417.86
References & Citations
[1]Sharma P, et al. Evolution of Small Molecule Inhibitors of Mycobacterium tuberculosis Menaquinone Biosynthesis. J Med Chem. 2025 Mar 13;68 (5) :5774-5803.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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