TREK inhibitor-3
TREK inhibitor-3 (Cpd8l) is a selective and BBB-permeable TREK-1 inhibitor with an IC50 of 0.81 μM. TREK inhibitor-3 has neuroprotective effects, which can significantly reduce the death of cortical neurons induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and improve brain injury in mice models of middle cerebral artery occlusion/reperfusion (MCAO/R) . TREK inhibitor-3 can be used in the research of ischemic stroke[1].
Product Specifications
CAS Number
[3023854-95-4]
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
O=C1C2=CC(C3CCNCC3)=CC=C2C(O1)CC4=CC=CC=C4C
Molecular Formula
C21H23NO2
Molecular Weight
321.41
References & Citations
[1]Liu K, et al. Discovery of Isobenzofuran-1 (3H) -one Derivatives as Selective TREK-1 Inhibitors with In Vitro and In Vivo Neuroprotective Effects. J Med Chem. 2025 Mar 13;68 (5) :5804-5823.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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