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SHP2-IN-36

SHP2-IN-36 (Compound B8) is an allosteric inhibitor of SHP2, with an IC50 value of 9.0 nM. In addition, its IC50 for p-ERK is 40 nM. SHP2-IN-36 also exhibited significant antitumor activity in the KYSE520 xenograft mouse model. SHP2-IN-36 can be used for research in the field of anti-tumor [1].

Product Specifications

UNSPSC

12352005

Target

SHP2

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

N[C@H]1C2(CCN(C3=NC=C(SC4=C5OC[C@@](CCC6)([H])N6C5=NC=C4)C7=NN=CN37)CC2)CC8=C1C=CC=C8

Molecular Formula

C28H30N8OS

Molecular Weight

526.66

References & Citations

[1]Shi C, et al. Development of Potent SHP2 Allosteric Inhibitors: Design, Synthesis, and Evaluation with Antitumor Effects. J Med Chem. 2025 Mar 13;68 (5) :5238-5256.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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