SHP2-IN-36
SHP2-IN-36 (Compound B8) is an allosteric inhibitor of SHP2, with an IC50 value of 9.0 nM. In addition, its IC50 for p-ERK is 40 nM. SHP2-IN-36 also exhibited significant antitumor activity in the KYSE520 xenograft mouse model. SHP2-IN-36 can be used for research in the field of anti-tumor [1].
Product Specifications
UNSPSC
12352005
Target
SHP2
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
N[C@H]1C2(CCN(C3=NC=C(SC4=C5OC[C@@](CCC6)([H])N6C5=NC=C4)C7=NN=CN37)CC2)CC8=C1C=CC=C8
Molecular Formula
C28H30N8OS
Molecular Weight
526.66
References & Citations
[1]Shi C, et al. Development of Potent SHP2 Allosteric Inhibitors: Design, Synthesis, and Evaluation with Antitumor Effects. J Med Chem. 2025 Mar 13;68 (5) :5238-5256.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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