MC4762
MC4762 is an inhibitor of NOX2 and MAOB, with IC50 values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines iNOS, IL-1β, and IL-6[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; Monoamine Oxidase; NADPH Oxidase; NO Synthase; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Field of Research
Inflammation/Immunology
Smiles
C#CCN(CC1=CC=C(CN2N=NC3=C(SC4=NC5=CC=CC=C5O4)N=CN=C32)C=C1)C
Molecular Formula
C23H19N7OS
Molecular Weight
441.51
References & Citations
[1]Noce B, et al. Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor. J Med Chem. 2025 Mar 5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAO-B; NOX2
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