GLI1-IN-3
GLI1-IN-3 (Compound 11a), a triterpenoid analogue, can inhibit Hedgehog signaling in GLI1 overexpression cancer cells. GLI1-IN-3 inhibits the proliferation in NSCLC and prostate cancer cell lines exhibiting hyper-activated Hh signaling. GLI1-IN-3 can also decrease the expression of endogenous GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells[1].
Product Specifications
UNSPSC
12352211
Target
Hedgehog
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Smiles
CC1(C)C(C(C2=CC=CO2)=C[C@]3(C)[C@@]4([H])CC[C@]5([H])[C@@]6([H])[C@H](C(C)=C)CC[C@@](C(O)=O)6CC[C@](C)5[C@@](C)4CC[C@@]13[H])=O
Molecular Formula
C34H46O4
Molecular Weight
518.73
References & Citations
[1]Frydrych I, et, al. Novel C-2 Aromatic Heterocycle-Substituted Triterpenoids Inhibit Hedgehog Signaling in GLI1 Overexpression Cancer Cells. ACS Omega. 2025 Mar 4;10 (10) :10617-10632.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC741970-500 1x 500 µL
Thyroglobulin (Thyroidal Cell Marker) (TGB/1970R), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
PKSH032379-01 10 µg
Recombinant Human Endoglin/CD105 Protein (His&Trx Tag)
Sign In for Pricing
View Details PKSH032379-02 50 µg
Recombinant Human Endoglin/CD105 Protein (His&Trx Tag)
Sign In for Pricing
View Details 
BNC741922-100 1x 100 µL
TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1922), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
![GABPB2 (GABPB1) Mouse Monoclonal Antibody [Clone ID: OTI4D5]](https://cdn.genprice.uk/products/937/68dd18bb061270361e908ad3/imageurl/cf811261.webp)
CF811261 100 µg
GABPB2 (GABPB1) Mouse Monoclonal Antibody [Clone ID: OTI4D5]
Sign In for Pricing
View Details