GLI1-IN-3
GLI1-IN-3 (Compound 11a), a triterpenoid analogue, can inhibit Hedgehog signaling in GLI1 overexpression cancer cells. GLI1-IN-3 inhibits the proliferation in NSCLC and prostate cancer cell lines exhibiting hyper-activated Hh signaling. GLI1-IN-3 can also decrease the expression of endogenous GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells[1].
Product Specifications
UNSPSC
12352211
Target
Hedgehog
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Smiles
CC1(C)C(C(C2=CC=CO2)=C[C@]3(C)[C@@]4([H])CC[C@]5([H])[C@@]6([H])[C@H](C(C)=C)CC[C@@](C(O)=O)6CC[C@](C)5[C@@](C)4CC[C@@]13[H])=O
Molecular Formula
C34H46O4
Molecular Weight
518.73
References & Citations
[1]Frydrych I, et, al. Novel C-2 Aromatic Heterocycle-Substituted Triterpenoids Inhibit Hedgehog Signaling in GLI1 Overexpression Cancer Cells. ACS Omega. 2025 Mar 4;10 (10) :10617-10632.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNUM0159-50 1x 50 µL
Mucin 1 / EMA / Episialin / CD227 (GP1.4), 1mg/mL
Sign In for Pricing
View Details 
![FAK (PTK2) pTyr397 (incl. pos. control) Mouse Monoclonal Antibody [Clone ID: 2D11]](https://cdn.genprice.uk/products/937/68dd1899061270361e8fb5ed/imageurl/am00059pu-n.webp)
AM00059PU-N 100 µg
FAK (PTK2) pTyr397 (incl. pos. control) Mouse Monoclonal Antibody [Clone ID: 2D11]
Sign In for Pricing
View Details