SMARCA2/4-ligand-5

SMARCA2/4-ligand-5 is a SMARCA2/4 ligand for PROTAC SMARCA2/4 degrader-37 (Example 4) . PROTAC SMARCA2/4 degrader-37 (Example 4) is a PROTAC-based SMARCA2/4 degrader, with an IC50 of ≤0.1 μM[1].

Product Specifications

CAS Number

[2271348-89-9]

UNSPSC

12352005

Target

Epigenetic Reader Domain; Ligands for Target Protein for PROTAC

Related Pathways

Epigenetics; PROTAC

Field of Research

Others

Smiles

O=C(NC1=CC(C#CC2=CC=CC(C(O)=O)=C2)=NC=C1)NC3=CC(Cl)=NC=C3

Molecular Formula

C20H13ClN4O3

Molecular Weight

392.80

References & Citations

[1]Deyao LI, et al. Preparation of bifunctional PROTAC compounds, compositions, and methods for degradation of targeted SMARCA2, SMARCA4 or BRM proteins. Patent WO2021163302 A1.