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Dirozalkib

Dirozalkib (Compound 4) is the inhibitor for ALK with an IC50 of 0.9 nM. Dirozalkib exhibits anti-proliferative activity in cancer cells NCI-H3122, Karpas-299 and NCI-H2228 with IC50s of 130.4, 0.71 and 15.11 nM, respectively. Dirozalkib exhibits good pharmacokinetics characteristics with an bioavailbility of 30%~50%[1].

Product Specifications

CAS Number

1893419-37-8

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK)

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=S(C1=C(NC2=NC(NC3=C4OCCOC4=C(C5CCNCC5)C(C)=C3)=NC=C2Cl)C=CC=C1)(C(C)C)=O

Molecular Formula

C27H32ClN5O4S

Molecular Weight

558.09

References & Citations

[1]Wu Y, et al., Polycyclic anaplastic lymphoma kinase inhibitor. WO2016050171

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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