Dirozalkib
Dirozalkib (Compound 4) is the inhibitor for ALK with an IC50 of 0.9 nM. Dirozalkib exhibits anti-proliferative activity in cancer cells NCI-H3122, Karpas-299 and NCI-H2228 with IC50s of 130.4, 0.71 and 15.11 nM, respectively. Dirozalkib exhibits good pharmacokinetics characteristics with an bioavailbility of 30%~50%[1].
Product Specifications
CAS Number
[1893419-37-8]
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=S(C1=C(NC2=NC(NC3=C4OCCOC4=C(C5CCNCC5)C(C)=C3)=NC=C2Cl)C=CC=C1)(C(C)C)=O
Molecular Formula
C27H32ClN5O4S
Molecular Weight
558.09
References & Citations
[1]Wu Y, et al., Polycyclic anaplastic lymphoma kinase inhibitor. WO2016050171
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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